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Quadratox is a panel of bone marrow-derived mononuclear cells from four different mammalian species including inbred C57BL/6 mice, purebred beagles, baboons and humans. Cells are obtained after IRB approval of AAALAC accredited facilities. Quadratox can be used to assess the relative toxicities of chemotherapeutic drugs in pre-clinical research. Inter-species differences in the relative toxicities of numerous chemotherapeutic drugs are well documented. In vitro toxicity data have been shown to contribute to both the structuring and subsequent interpretation of clinical trials. Quadratox Panels may be used for selection of the most appropriate animal models for both efficacy and toxicology studies and prediction of in vivo human myelotoxicity. The Quadratox 4-Species Panel is available as cryopreserved vials of 5 million cells/species. Bone marrow mononuclear cells from human, murine, canine, and baboon are also available individually. |
